Endocrine Abstracts

Introduction: The association of fasting glucose (FG) in early pregnancy (EP) with adverse outcomes for the mother and her offspring is well known, although the best cut-offs for diagnosis of Gestational Diabetes (GD) are not consensual.Objetive: Evaluate the impact of FG in EP in the management of pregnant women and obstetric and fetal outcomes.Methods: Retrospective cohort of pregnant women with GD diagnosed before 24 weeks of ge...

Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregnancy, leading to adverse neonatal and obstetric outcomes.Objective: To evaluate the influence of maternal prepregnancy body mass index (BMI) on blood glucose levels at diagnosis of gestational diabetes (GD), obstetric and neonatal outcomes.Methods: Retrospective observational study including women with GD and singleton pregnancy, with fo...

Introduction and aim: Type 1 diabetes mellitus (T1DM) presents as a challenge for both health care providers and patients looking to avoid chronic complications and early mortality. Clinical features of patients with long duration T1DM are still poorly studied and debated. The aim of our work was to describe the clinical features of subjects with long duration T1DM.Methods: Cross-sectional study of patients with T1DM with more than 40 years of evolution ...

Introduction: The American Diabetes Association proposed two subcategories for type 1 diabetes: autoimmune type 1 diabetes (ADM) and idiopathic type 1 diabetes (IDM). The absence of β-cell autoimmune markers and lack of association with HLA haplotypes define the second category, whose pathogenesis remains unclear. Only a minority of patients with type 1 diabetes fall into this subcategory which is considered by several authors similar to type 2 diabetes.<p class="abst...

Introduction: The American Diabetes Association proposed two categories for the classification of type 1 diabetes mellitus (DM): autoimmune (AI) and idiopathic (ID). The absence of autoimmune markers or association with HLA haplotypes defines the second category. Only a small minority of patients with type 1 diabetes fall into this category.Objective: To evaluate the clinical characteristics of both categories and to analyze the differe...

Introduction: The American Diabetes Association guideline states that the long-term use of metformin may be associated with biochemical vitamin B12 (B12) deficiency and periodic measurement should be considered, although isolated serum B12 measurement has low sensitivity and specificity. Homocysteine (Hcy) and methylmalonic acid (MMA) are more sensitive biomarkers, the latter being more specific.Objectives: To estimate B12 deficiency in type 2 diabetics ...

Introduction: MEN1 is a rare autosomal dominant syndrome typically characterized by neoplastic lesions of parathyroid glands, anterior pituitary gland and endocrine pancreas. Several other tumours are associated with this syndrome, including adrenal lesions, but their prevalence and clinical characteristics (endocrine secretion and aggressiveness) are largely unknown.Objective: To determine the prevalence, clinical characteristics and the possible genoty...

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for maternal-fetal complications and development of diabetes or intermediate hyperglycemia after pregnancy. The follow-up should be done by a multidisciplinary team. After delivery, all women diagnosed with GDM should undergo an oral glucose tolerance test (OGTT) for reclassificationAim: To evaluate the non-adherence factors to reclassification OGTT after GDM.Method...

Introduction: Maturity onset diabetes of the young (MODY) accounts for 1-2% of all forms of diabetes mellitus (DM). As classic criteria that lead to its suspicion have low sensitivity, patients are often misdiagnosed with type 1 or type 2 DM. Correct classification of this type of diabetes becomes essential for proper management of the disease. Our objective was to describe clinical features of patients with MODY diagnosed at our institution.Methods: We ...

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for large for gestational age (LGA) newborns. The optimization of glycemic control and weight gain restriction during pregnancy according to BMI has contributed to decrease LGA but may increase the risk of small for gestational age (SGA).Aim: To evaluate the predictors of SGA in women with DGM.Methods: A cohort of 5271 Portuguese women from the National Registry of ...